O.N.E Multivitamin by Pure Encapsulations

PRO's

• Generally safe for most healthy adults
• Uses high-quality, bioavailable (methylated) forms of most nutrients for better absorption
• Third-party tested
• No contaminants, heavy metals, or allergens

CON's

• Company got purchased by Nesté in 2007 and is now a division of Nestlé Health. Not too worrying as they also own Vital Proteins and Garden of Life which are two other brands known for high quality ingredients
• There are a few unnecessarily high dosages of vitamins and minerals
• Missing some vital nutrients which means you have to take multiple forms of supplements to get all the nutrients you need.
• Uses a few synthetic compounds/elements

WHY it gets our stamp of approval:

1. Non-GMO & no pesticides or herbicides 
2. No Artificial sweeteners, Added sugar, Erythritol, Monk fruit, MSG
3. Natural healthy ingredients
4. Very few synthetic elements/compounds which is top percentile compare to other multivitamins on the market
5. No known harmful chemicals, contaminants, or additives

If taking other medications or drugs use their Drug Nutrient Interaction Checker

Supplement Analysis

This supplement contains mostly safe ingredients, but there are a few components where dosage could potentially lead to issues if not monitored properly, especially if taken along with other supplements or a nutrient-rich diet. In particular, vitamins A, E, zinc, chromium, and selenium should be monitored to avoid excessive intake.

Overview

• Overall Safety: The multivitamin appears well-formulated, with attention to bioavailable nutrient forms (e.g., L-5-MTHF, methylcobalamin). The ingredients are clean, with no artificial additives, which aligns with a high-quality standard.
• Potential Issues: There could be some concern with prolonged use of higher doses of Zinc, Vitamin D3, and Chromium, B12, and B7. Especially when combined with other supplements or dietary sources of these nutrients. Regular blood tests might be advisable to monitor levels, particularly of vitamin D and zinc.
• Suitability: This multivitamin is well-suited for individuals seeking a high-potency supplement with minimal fillers, or individuals with B vitamin deficicines.

Conclusion

Caution is recommended for those who may already be taking additional individual supplements of the same nutrients OR individuals who get complete nutrition from dieting.

Potentially Concerning Levels

Vitamin B12 (Methylcobalamin) - 500 mcg (20,833% DV)

• Current: Methylcobalamin, high quality best form of B12
• Generally considered safe as excess is excreted. However, such high levels may: Interfere with some lab tests, Be unnecessary for most people, mask symptoms of other deficiencies in rare cases.

Chromium - 200 mcg (571% DV)

• While generally safe, high doses may: Interfere with iron absorption, Cause stomach irritation in some people, Interact with certain medications
• Potential Issues: Chromium is often added to supplements for blood sugar regulation, but high amounts (200 mcg is quite high) can sometimes interfere with insulin function or lead to gastrointestinal discomfort.

Zinc - 25 mg (227% DV)

• Suggestion: Current level (25 mg) may be high for daily use, can lower dosage
• High doses can: Interfere with copper absorption, Cause nausea or stomach upset, Impact immune function if taken long-term

Biotin - B7 - 300 mcg (1,000% DV)

• Generally safe but: Can interfere with certain lab tests, May be unnecessarily high for most people

Other Considerations

Vitamin A - 1,125 mcg (125% DV)

• Current: Mix of acetate and beta carotene 
• Could benefit from: More beta carotene or mixed carotenoids 
• Rationale: Body converts as needed, lower risk of excess
• High Dosage Warning: Within safe range, but as a fat-soluble vitamin, it can accumulate. The combination of vitamin A acetate and beta-carotene yields a significant amount of vitamin A. Excess vitamin A (especially from retinol/retinyl forms, as opposed to beta-carotene) can lead to toxicity, with symptoms such as liver damage or bone loss. It’s particularly important not to exceed recommended doses for extended periods.

Vitamin D - 50 mcg (250% DV)

• Generally safe at this level for most adults
• Monitor if taking other vitamin D supplements
• Safe within Limits: The dosage shown is 50 mcg (2000 IU), which is generally safe and even recommended for many adults. However, excessive vitamin D intake over time could lead to hypercalcemia, potentially causing kidney issues.

Selenium - 70 mcg (127% DV)

• Within safe range but can be toxic at higher levels
• Safe with Caution: Selenium is important for antioxidant defense and thyroid health. However, excessive selenium (>400 mcg/day) can lead to selenosis, causing symptoms like hair loss, gastrointestinal upset, and nerve damage. The dosage in this supplement (70 mcg) is reasonable but should be monitored if combined with other selenium sources.

Vitamin E

• Current: d-alpha tocopherol succinate
• Better option: Mixed tocopherols (alpha, beta, gamma, delta)
• Rationale: Full spectrum provides more comprehensive benefits

Molybdenum

• High Dosage Warning: The dosage of molybdenum is 75 mcg (167% of daily value). While not extremely high, excess molybdenum can lead to symptoms like joint pain or may interfere with copper absorption, which is critical for bodily functions.

Alpha-Lipoic Acid (ALA)

• Potential Issues: Alpha-lipoic acid at 50 mg is considered generally safe. However, it can lower blood sugar levels, which could be problematic for those with hypoglycemia or those on diabetes medication. Additionally, gastrointestinal side effects can occur in some individuals.
• Suggestion: Increasing the dose to 100-200 mg might offer more significant antioxidant benefits, especially in individuals needing better metabolic support.

Niacin (Niacinamide) 

• Flushing Risk: Niacinamide is a non-flushing form of niacin, which makes it generally safe. However, at higher doses, it could still lead to mild gastrointestinal issues or liver stress.

Boron

• Generally Safe, But No DV Established: Boron is important for bone health but is not an essential nutrient. Excessive intake could affect hormone levels and lead to negative symptoms, though the 1 mg in this supplement is very low.

Coenzyme Q10 (CoQ10) 

• Suggestion: Increasing the dose to 100-200 mg might offer more significant cardiovascular and cellular energy support.
• Generally Safe: CoQ10 at 50 mg is widely used and generally safe. The primary concern is potential interaction with blood-thinning medication, as CoQ10 might decrease their effectiveness.

Inositol 

• Generally Safe: Inositol is used for nerve signaling and may help with mental health. High doses are usually well-tolerated, although they can cause mild gastrointestinal side effects.

Other Ingredients:

• Lutein, Zeaxanthin, Lycopene: These are carotenoids, generally considered safe and beneficial for eye health and antioxidant support. 
• Choline (as Choline Bitartrate): The 10 mg included is very low. Choline is important for brain health, and there is minimal risk at this dosage. Citicoline (CDP-choline) or Alpha-GPC are better options for enhanced bioavailability and cognitive benefits. Increasing the dosage would also provide greater benefit, as most adults require significantly more choline for optimal health.

Most other ingredients are either:

• At reasonable levels
• Water-soluble (excess is excreted)
• Have no established upper limit

Summary of Potential Concerns & Improvements:

Vitamin A (retinyl acetate): 

• Excessive intake could lead to toxicity. It’s important to watch total daily intake from all sources.
• Reduce retinyl acetate in favor of more beta-carotene to prevent toxicity.

Chromium and Zinc: 

• Both are present in relatively high amounts. Chronic high intake could lead to potential side effects like insulin resistance or interference with copper metabolism.

Vitamin E: Potential for bleeding risk, especially in those on blood thinners.

• Opt for mixed tocopherols instead of just alpha-tocopherol for a broader antioxidant benefit.

Selenium: 

High intake should be monitored if combined with other selenium-containing supplements.

• Vitamin B6: Use only Pyridoxal-5-Phosphate for better bioavailability.
• Choline: Switch to Citicoline or Alpha-GPC and increase the dose for better cognitive support.
• Carotenoids (Lutein, Zeaxanthin): Increase dosage to recommended levels for eye health.
• CoQ10: Increase the dosage for better cardiovascular support.

Missing or Low Nutrients

Magnesium

• Why it's essential: Critical for energy production, Important for DNA repair, Supports cardiovascular health
• Recommended form: Magnesium glycinate or malate

Vitamin K2 (MK-7)

• Why it's essential: Directs calcium to bones instead of arteries, Supports cardiovascular health, Works synergistically with D3.

Omega-3 Fatty Acids

• Why they're essential: Anti-inflammatory properties, Support brain health, Cardiovascular benefits
• Recommended form: EPA and DHA from fish oil or algae

Potassium 

• Why it’s essential: Potassium plays a vital role in maintaining normal blood pressure, muscle contraction, and nerve transmission

Copper

• Trace minerals such as copper are needed in small quantities but are essential for processes like iron metabolism and immune function

Iron

• Iron is crucial for oxygen transport and energy metabolism, small dosage can be very beneficial

Calcium

• Why it’s essential: Critical for bone health, muscle function, and vascular contraction

Complete Vitamin E Complex

• Current formula only includes alpha-tocopherol. Missing Gamma-tocopherol & Tocotrienols

Timing and Absorption Considerations

Fat-Soluble Vitamins

• Current formula combines all in one dose
• Consider splitting:
• Morning: Water-soluble vitamins
• Evening with meal: Fat-soluble vitamins

Mineral Competitions

• Zinc and iron compete for absorption
• Calcium can interfere with other minerals